Alcaloïdes indolomonoterpéniques isolés de rauvolfia caffra sond et tabernaemontana penduliflora k. schum (apocynaceae): isolement, détermination structurale et activités biologiques

Abstract

A exhibited potent antibacterial activities with MIC values in the range 6.25–25 μg.mL−1 and were characterized as weak apoptosis inducers in HCT116 human colon carcinoma cell line. Antiplasmodial activity of penduliflorines A-E and voacangine-N-oxide were evaluated against two strains of Plasmodium falciparum 3D7 and Dd2. These compounds showed good in vitro activity. Among them, penduflorine A and tabernaemontine showed significant inhibitory activity against the two strains with IC50 values in the range 1.85–7.88 µg/mL comparable to those of Artemisinin and Chloroquine, and the others exhibited moderate activity.